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PUBLICATIONS

TALETRECTINIB

Journal of Clinical Oncology

Long-Term Efficacy and Safety of Taletrectinib in Patients With ROS1+ Non-Small Cell Lung Cancer: Results From the Phase II TRUST-I Study

AACR 2026 Oral Presentation

Taletrectinib in TKI-Naïve Patients With ROS1+ NSCLC: Updated Data From TRUST-I and TRUST-II

AACR 2026 Poster Presentation

Taletrectinib, a Next-Generation Selective ROS1 Inhibitor, Inhibits TRKB Signaling-Induced Invasive Potential of Lung Cancer Cells

AACR 2026 Poster Presentation

Taletrectinib in TKI-Pretreated Patients With ROS1+ Non-Small Cell Lung Cancer: Updated Data From TRUST-I and TRUST-II

ELCC 2026 Poster Presentation

Characterization of the Safety Profile of Taletrectinib in Patients With Advanced ROS1+ Non-Small Cell Lung Cancer: Results From TRUST-I and TRUST-II

TTLC 2026 Poster Presentation

Efficacy and Safety of Taletrectinib in Patients With ROS1+ NSCLC: Updated Safety Analysis From the Phase 2 TRUST-I and TRUST-II Studies

ESMO Asia 2025 Poster Presentation

Subgroup Analysis of Japanese Patients in the Phase II Study of Taletrectinib in Patients with ROS1+ NSCLC: The Global TRUST-II Study

ESMO 2025 Poster Presentation

TRUST-II Global Study: Efficacy and Safety of Taletrectinib After Prior Entrectinib Exposure in Patients With Advanced ROS1+ Non-Small Cell Lung Cancer

WCLC 2025 Mini Oral Presentation

Updated Efficacy and Safety of Taletrectinib in Patients With ROS1+ Non-Small Cell Lung Cancer: The Global TRUST-II Study

WCLC 2025 Poster Presentation

Updated Efficacy and Safety of Taletrectinib in Chinese Patients With ROS1+ Non-Small Cell Lung Cancer: Phase 2 TRUST-I Study

WCLC 2025 Poster Presentation

Clinical Pharmacologic Characteristics of Taletrectinib

WCLC 2025 Poster Presentation

TRUST-III: Phase 3 Head-to-Head Study of Taletrectinib vs Crizotinib in Patients With ROS1+ Non-Small Cell Lung Cancer (NCT06564324)

WCLC 2025 Poster Presentation

Taletrectinib, a Next-Generation Selective ROS1 Inhibitor, Exhibits a Differentiated Profile in ROS1 Fusion Models

ASCO 2025 Poster Presentation

Comparable Efficacy and Safety of Taletrectinib for Advanced ROS1+ Non-small Cell Lung Cancer Across Pivotal Studies and Between Races and World Regions

ISPOR 2025 Poster Presentation

Taletrectinib vs Entrectinib in ROS1-Positive (ROS1+) Non-Small Cell Lung Cancer (NSCLC): A Matching-Adjusted Indirect Comparison (MAIC)

AACR 2025 Poster Presentation

Taletrectinib, a next-generation selective ROS1 inhibitor, inhibits growth of ROS1 wild-type and ROS1-G2032R xenografts

Journal of Clinical Oncology

Taletrectinib in ROS1+ Non–Small Cell Lung Cancer: TRUST

ELCC 2025 Mini Oral Presentation

Taletrectinib vs. Crizotinib in ROS1-Positive Non-Small Cell Lung Cancer: A Matching-Adjusted Indirect Comparison

ESMO 2024 Poster Presentation

Pooled Efficacy and Safety From 2 Pivotal Phase 2 Trials of Taletrectinib in Patients With Advanced or Metastatic ROS1+ Non–Small Cell Lung Cancer

WCLC 2024 Oral Presentation

Efficacy and Safety of Taletrectinib in Patients with ROS1+ Non–Small Cell Lung Cancer: The Global TRUST-II Study

Journal of Clinical Oncology

Efficacy and Safety of Taletrectinib in Chinese Patients with ROS1+ Non-Small Cell Lung Cancer: The Phase II TRUST-I Study

DOI: 10.1200/JCO.24.00731

ASCO 2024 Oral Presentation

Efficacy and Safety of Taletrectinib in Patients with Advanced or Metastatic ROS1+ Non-Small Cell Lung Cancer: The Phase 2 TRUST-I Study

ESMO 2023 Poster Presentation

Efficacy and Safety of Taletrectinib in Patients with ROS1+ NSCLC: Interim Analysis of Global TRUST-II Study

ELCC 2023 Mini Oral Presentation

Updated Efficacy and Safety of Taletrectinib in Patients with ROS1+ Non–Small Cell Lung Cancer

Future Oncology

TRUST-II: a Global Phase II Study of Taletrectinib in ROS1-Positive Non-Small-Cell Lung Cancer and Other Solid Tumors

PMID: 36877099

ASCO 2022 Poster Presentation

TRUST: The Efficacy and Safety of Taletrectinib in TKI-Naïve or Crizotinib-Pretreated ROS1-Positive Non-Small Cell Lung Cancer (NSCLC) Patients

ELCC 2022 Poster Presentation

A Global Phase 2 Study of Taletrectinib, a Next Generation of ROS1 TKI, in ROS1 Positive Lung Cancer and Other Solid Tumors (TRUST II)

CSCO 2021 Oral Presentation

A Phase II Clinical Study to Investigate Taletrectinib (AB-106) in Treating Patients with ROS1 Fusion Positive Non-Small Cell Lung Cancer (TRUST Phase II study)

ASCO 2021 Poster Presentation

Preliminary Results from TRUST: A Phase II Clinical Study to Investigate Taletrectinib in Treating Patients with ROS1 Fusion Positive Non-small Cell Lung Cancer (NSCLC)

JTO Clinical and Research Reports

Efficacy of Taletrectinib (AB-106/DS-6051b) in ROS1+ NSCLC: An Updated Pooled Analysis of U.S. and Japan Phase 1 Studies

PMID: 34589973 PMCID: PMC8474193
DOI: 10.1016/j.jtocrr.2020.100108

Clinical Cancer Research

U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors

PMID: 32591465
DOI: 10.1158/1078-0432.CCR-20-1630

Nature Communications

The New-Generation Selective ROS1/NTRK Inhibitor DS-6051b Overcomes Crizotinib Resistant ROS1-G2032R Mutation in Preclinical Models

PMID: 31399568 PMCID: PMC6688997
DOI: 10.1038/s41467-019-11496-z

Oncotarget

Safety and Pharmacokinetics of DS-6051b in Japanese Patients with Non-small Cell Lung Cancer Harboring ROS1 Fusions: a Phase I Study

PMID: 29805770 PMCID: PMC5955103
DOI: 10.18632/oncotarget.25263

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